Vaccination-induced HI antibody to influenza A(H1N1) viruses in poorly primed adults under circumstances of low antigenic drift
Identifieur interne : 001E60 ( Main/Exploration ); précédent : 001E59; suivant : 001E61Vaccination-induced HI antibody to influenza A(H1N1) viruses in poorly primed adults under circumstances of low antigenic drift
Auteurs : R. Pyh L [Finlande] ; L. Kinnunen [Finlande] ; V. Kumpulainen [Finlande] ; N. Ikonen [Finlande] ; M. Kleemola [Finlande] ; K. Cantell [Finlande]Source :
- Vaccine [ 0264-410X ] ; 1993.
English descriptors
- Teeft :
- Amino, Amino acid differences, Amino acids, Antibody, Antibody reactivity, Antibody response, Antibody responses, Antibody titres, Antigenic, Antigenic analysis, Antigenic differences, Antigenic drift, Cell cultures, Clinical material, Conspicuous decreases, Elderly people, Embryonated eggs, Epidemic influenza, Epidemic season, Epidemiol, Field strains, First time, Genembl data base, Haemagglutinin, Higher prevaccination, Human sera, Immune response, Immunological memory, Influenza, Influenza vaccine, Influenza virus, Influenza viruses, Latter viruses, Mammalian virus, Mdck, Mdck cell cultures, Older people, Older subjects, Postepidemic, Postepidemic antibody titres, Postvaccination, Postvaccination protection rates, Postvaccination sera, Present study, Prevaccination, Prevaccination antibody, Prevaccination antibody titres, Protection rate, Protection rates, Reference strains, Response rate, Sequence analysis, Seronegative subjects, Seroneoative subjects, Subtype, Subtype viruses, Successive samples, Titre, Trivalent, Trivalent influenza virus vaccine, Vaccine, Vaccine strain, Vaccine virus, Virol, Virus, Virus antigens, Virus haemagglutinin, Virus strain, Wkly epidemiol, World health organization, Young adults, Younger subjects.
Abstract
Abstract: In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11–12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in lowered haemagglutination-inhibiting (HI) antibody responses to the latter viruses. In fact, higher prevaccination, postvaccination and postepidemic antibody titres were recorded against the new field strains than against the vaccine virus; the highest being against field strains grown exclusively in MDCK cell cultures. This pattern is primarily explained by differences in the sensitivity of the viruses for detecting HI antibodies. Postvaccination protection rates of 98–100% for the MDCK-grown avid viruses were noted in subjects who exhibited prevaccination antibody. Lower protection rates were recorded in initially seronegative subjects, the lowest (54–57%) being among older people, i.e. among vaccinees born in 1930–1955 (p < 0.001). Moreover, conspicuous decreases in protection rates were detected during the following epidemic season in the initially seronegative subjects. Diagnostic findings during outbreaks due to H1N1 subtype viruses also support the impression that many middle-aged people are poorly primed. Thus, vaccination with two doses may be worth considering when such people join the high-risk group and receive influenza vaccine for the first time.
Url:
DOI: 10.1016/0264-410X(93)90126-I
Affiliations:
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Kumpulainen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki City Occupational Health Care Unit, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Ikonen, N" sort="Ikonen, N" uniqKey="Ikonen N" first="N." last="Ikonen">N. Ikonen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>National Public Health Institute, Mannerheimintie 166, 00300 Helsinki</wicri:regionArea><wicri:noRegion>00300 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kleemola, M" sort="Kleemola, M" uniqKey="Kleemola M" first="M." last="Kleemola">M. 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Cantell</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>National Public Health Institute, Mannerheimintie 166, 00300 Helsinki</wicri:regionArea><wicri:noRegion>00300 Helsinki</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1013">1013</biblScope><biblScope unit="page" to="1017">1017</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amino</term><term>Amino acid differences</term><term>Amino acids</term><term>Antibody</term><term>Antibody reactivity</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody titres</term><term>Antigenic</term><term>Antigenic analysis</term><term>Antigenic differences</term><term>Antigenic drift</term><term>Cell cultures</term><term>Clinical material</term><term>Conspicuous decreases</term><term>Elderly people</term><term>Embryonated eggs</term><term>Epidemic influenza</term><term>Epidemic season</term><term>Epidemiol</term><term>Field strains</term><term>First time</term><term>Genembl data base</term><term>Haemagglutinin</term><term>Higher prevaccination</term><term>Human sera</term><term>Immune response</term><term>Immunological memory</term><term>Influenza</term><term>Influenza vaccine</term><term>Influenza virus</term><term>Influenza viruses</term><term>Latter viruses</term><term>Mammalian virus</term><term>Mdck</term><term>Mdck cell cultures</term><term>Older people</term><term>Older subjects</term><term>Postepidemic</term><term>Postepidemic antibody titres</term><term>Postvaccination</term><term>Postvaccination protection rates</term><term>Postvaccination sera</term><term>Present study</term><term>Prevaccination</term><term>Prevaccination antibody</term><term>Prevaccination antibody titres</term><term>Protection rate</term><term>Protection rates</term><term>Reference strains</term><term>Response rate</term><term>Sequence analysis</term><term>Seronegative subjects</term><term>Seroneoative subjects</term><term>Subtype</term><term>Subtype viruses</term><term>Successive samples</term><term>Titre</term><term>Trivalent</term><term>Trivalent influenza virus vaccine</term><term>Vaccine</term><term>Vaccine strain</term><term>Vaccine virus</term><term>Virol</term><term>Virus</term><term>Virus antigens</term><term>Virus haemagglutinin</term><term>Virus strain</term><term>Wkly epidemiol</term><term>World health organization</term><term>Young adults</term><term>Younger subjects</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: In Autumn 1990, trivalent split influenza virus vaccine containing A/Taiwan/1/86(H1N1) was used to immunize healthy female employees (n = 104). The 11–12 amino acid differences in the HA1 domain of virus haemagglutinin between A/Taiwan/1/86 and representative epidemic H1N1 strains in Finland in 1991 did not result in lowered haemagglutination-inhibiting (HI) antibody responses to the latter viruses. In fact, higher prevaccination, postvaccination and postepidemic antibody titres were recorded against the new field strains than against the vaccine virus; the highest being against field strains grown exclusively in MDCK cell cultures. This pattern is primarily explained by differences in the sensitivity of the viruses for detecting HI antibodies. Postvaccination protection rates of 98–100% for the MDCK-grown avid viruses were noted in subjects who exhibited prevaccination antibody. Lower protection rates were recorded in initially seronegative subjects, the lowest (54–57%) being among older people, i.e. among vaccinees born in 1930–1955 (p < 0.001). Moreover, conspicuous decreases in protection rates were detected during the following epidemic season in the initially seronegative subjects. Diagnostic findings during outbreaks due to H1N1 subtype viruses also support the impression that many middle-aged people are poorly primed. Thus, vaccination with two doses may be worth considering when such people join the high-risk group and receive influenza vaccine for the first time.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name></noRegion><name sortKey="Cantell, K" sort="Cantell, K" uniqKey="Cantell K" first="K." last="Cantell">K. Cantell</name><name sortKey="Ikonen, N" sort="Ikonen, N" uniqKey="Ikonen N" first="N." last="Ikonen">N. Ikonen</name><name sortKey="Kinnunen, L" sort="Kinnunen, L" uniqKey="Kinnunen L" first="L." last="Kinnunen">L. Kinnunen</name><name sortKey="Kleemola, M" sort="Kleemola, M" uniqKey="Kleemola M" first="M." last="Kleemola">M. Kleemola</name><name sortKey="Kumpulainen, V" sort="Kumpulainen, V" uniqKey="Kumpulainen V" first="V." last="Kumpulainen">V. Kumpulainen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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